Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis
Identifieur interne : 001890 ( Main/Exploration ); précédent : 001889; suivant : 001891Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis
Auteurs : Rs Brown [États-Unis] ; Pr Arany [États-Unis]Source :
- Oral diseases [ 1354-523X ] ; 2014.
Abstract
Drug-induced gingival overgrowth (DIGO) is a disfiguring side effect of anti-convulsants, calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. Studies supporting this hypothesis are discussed.
Url:
DOI: 10.1111/odi.12264
PubMed: 24893951
PubMed Central: 5241888
Affiliations:
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A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. 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